Viscosity Testing in Pharmaceutical Formulation: Nneɛma titiriw a ɛsɛ sɛ wosusuw ho ma Asia Kesee Fam Apuei ne Afrika

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Ɔpɛpɔn da 20, 2020

Wɔ nnuruyɛ mu no, viscosity nyɛ parameter a wɔpaw — ɛka tẽẽ nnuru a wɔayi no adi suban, palatability, production line compatibility, ne final product stability. Wɔ nnuruyɛ adwumayɛbea ahorow a ɛwɔ Asia Kesee Fam Apuei ne Afrika, baabi a mmeae a ɛhɔ yɛ hyew kɛse, ɛhɔ yɛ nwini kɛse ne ɛka a wɔbɔ ho anohyeto a emu yɛ den yɛ nea wɔtaa yɛ no fam no, ɛsɛ sɛ wɔde wɔn adwene si so titiriw sɛ wɔbɛsɔ nneɛma a ɛyɛ den no ahwɛ.

Nea Enti a Viscosity Ho Hia Kɛse Wɔ Pharma Formulation Mu

Wɔ nnuruyɛ mu no, viscosity nyɛ parameter a wɔpaw — ɛka tẽẽ nnuru a wɔayi no adi suban, palatability, production line compatibility, ne final product stability.

Wɔ nsu dodow a wɔde fa anom (syrups, suspensions, ano aduru) fam no, viscosity na ɛkyerɛ sɛnea nnuru no fi nipadua no mu ntɛmntɛm. Viscosity a ɛkɔ soro dodo ma ɛyɛ brɛoo na ebetumi aka sɛnea ɛyɛ adwuma yiye; viscosity a ɛba fam dodo ma sedimentation anaasɛ phase separation, na ɛma dose pɛpɛɛpɛyɛ yɛ basaa. Wɔ injectables ho no, viscosity ka injection ahotɔ ne nnuru trɛw wɔ vivo. Wɔ ahosiesie a wɔde gu nipadua no so (gels, creams) ho no, viscosity na ɛkyerɛ sɛnea ɛtrɛw na ɛbata ho.

Asia Kesee Fam Apuei ne Afrika de tebea soronko bi ba: ɛsɛ sɛ nnuruyɛ adwumayɛbea ahorow a ɛwɔ saa mmeae yi no gyina nneɛma a wɔde sie ne akwantu mu mmeae a ɛhɔ yɛ hyew, ɛhɔ yɛ nwini kɛse ano. Wɔ Asia Kesee Fam Apuei no, afe biara sɛ wɔkyekyem pɛpɛɛpɛ a, nsu a ɛyɛ nwini betumi adu 80% anaa nea ɛboro saa, na ɔhyew常年在25°C-38°C; wɔ Afrika mmeae bi no, wim hyew tumi boro 40°C. Ɔhyew a ɛkɔ soro ma nnuru no sɛe ntɛmntɛm na ɛsakra sɛnea nnuru a wɔde yɛ nnuru no mu yɛ den no. Enti, ɛsɛ sɛ nnwumakuo a wɔrehyehyɛ adwumayɛbea anaa wɔretɔ nneɛma wɔ saa mpɔtam yi de nneɛma a atwa yɛn ho ahyia ka wɔn viscosity testing protocols ho.

Bio nso, nnuruyɛ adwumayɛbea ahorow a ɛwɔ Asia Kesee Fam Apuei ne Afrika taa hyia ɛka ho anohyeto a emu yɛ den. Eyi kyerɛ sɛ ɛsɛ sɛ wɔkari pɛ wɔ sɔhwɛ mu pɛpɛɛpɛyɛ ne ɛka a wɔbɔ. NDJ-1 series digital rotational viscometer, a ne dwumadie interface a ɛnyɛ den, sɔhwɛ pɛpɛɛpɛ a wotumi de ho to so, ne boɔ a ɛyɛ den no yɛ mfitiaseɛ pa ma QC laboratories wɔ saa mpɔtam yi.

Rotational Viscometer vs Flow Cup: Sɛnea Wɔpaw Ma Pharma

Nnuruyɛ mu nsuo a ɛyɛ den sɔhwɛ ahiadeɛ no yɛ soronko koraa wɔ nea ɛwɔ aduru a wɔde kata so ne ink mu — nnuru a ɛyɛ den no taa yɛ teateaa (5-5000 mPa·s), nanso ahwehwɛdeɛ a ɛfa pɛpɛɛpɛyɛ ne nea wɔsan yɛ no yɛ kɛseɛ paa. Enti, rotational viscometers ne ade titiriw a wɔpaw ma pharma.

Adwuma nnyinasosɛm a ɛwɔ rotational viscometer mu: spindle di akɔneaba wɔ ahoɔhare a ɛkɔ so daa wɔ nhwɛsode no mu, na wɔsusuw torque (resistance) a ɛwɔ spindle no so de bu viscosity ho akontaa. NDJ-1E + dijitaal rotational viscometer no de electromagnetic balance sensor mfiridwuma a ɛkɔ anim di dwuma, ɛma ±1% pɛpɛɛpɛyɛ ne ≤0.5% repeatability, di pharma QC ahwehwɛde ahorow ho dwuma koraa.

Nea ɛne eyi bɔ abira no, wɔde flow cup viscometers (Ford nkuruwa, Zahn nkuruwa) di dwuma titiriw wɔ coatings ne inks mu, a ɛyɛ pɛpɛɛpɛ a ɛba fam (mpɛn pii no ±5%), na ɛma ɛnyɛ nea ɛfata sɛ wɔde di dwuma wɔ pharma mu. Nanso, nkuruwa a ɛsen fa nsu mu no ma ɛyɛ mmerɛw, ɛho ka sua, na wontumi nsiesie, na ɛma ɛfata sɛ wɔhwehwɛ mu ntɛmntɛm wɔ afuw mu. Wɔ Asia Kesee Fam Apuei ne Afrika nnuruyɛ adwumayɛbea ahorow mu no, wɔtaa de nkuruwa a ɛsen di dwuma de sɔ nneɛma hwɛ ntɛmntɛm wɔ baabi a wɔyɛ nnuru no anim, bere a viscometers a ɛkyinkyini di aduruyɛdan mu nhwehwɛmu a ɛyɛ pɛpɛɛpɛ ho dwuma no.

DVPlus + series touchscreen viscometer no ne nea ɛkɔ akyiri a wɔpaw ma pharma. Ɛwɔ kɔla touchscreen a ne kɛse yɛ nsateakwaa 7, data a wɔkora so, USB export, ne automatic spindle recognition, na ɛma ɛfata titiriw ma pharma nnwuma a wohia GMP mmara sodi. Touchscreen dwumadie brɛ nteteeɛ akwansideɛ no ase — ɛho hia titire wɔ mpɔtam a adwumayɛfoɔ a wɔsakyera dɔɔso te sɛ Asia Kesee Fam Apueeɛ ne Afrika.

Nsɛnnennen a ɛwɔ Pharma Viscosity Testing mu wɔ SEA ne Afrika

Nnwumakuw a wɔyɛ nnuru wɔ Asia Kesee Fam Apuei ne Afrika hyia nsɛnnennen a wɔde sɔ nneɛma a ɛyɛ den hwɛ a ɛsono nea ɛwɔ Europa ne Amerika Atifi fam no, titiriw wɔ nneɛma abiɛsa mu: nneɛma a atwa yɛn ho ahyia, nneɛma a wɔde ma, ne talente.

Nneɛma a atwa yɛn ho ahyia ho nsɛnnennen: Ɔhyew ne ɔhyew a ɛkɔ soro betumi aka ɛlɛtrɔnik nneɛma ne nneɛma a ɛma wohu nneɛma a ɛma nsu yɛ hyew no. Wɔ Asia Kesee Fam Apuei no, afe biara sɛ wɔkyekyem pɛpɛɛpɛ a, nsu a ɛyɛ nwini betumi adu 80% anaa nea ɛboro saa, na ɔhyew常年在25°C-38°C; wɔ Afrika mmeae bi no, wim hyew tumi boro 40°C. Ɔhyew a ɛkɔ soro ma nnuru no sɛe ntɛmntɛm na ɛsakra sɛnea nnuru a wɔde yɛ nnuru no mu yɛ den no. Enti, ɛsɛ sɛ nnwuma a ɛwɔ saa mmeae yi de nneɛma a atwa yɛn ho ahyia ka wɔn viscosity testing protocols ho.

Nsɛnnennen a ɛwɔ nneɛma a wɔde ma mu: Nneɛma a wɔde ma a wɔde ma viscometer spare parts ne consumables (spindles, protective guards) wɔ Asia Kesee Fam Apuei ne Afrika no nnyinii pii te sɛ Europa ne Amerika Atifi fam. Sɛ wobɛpaw obi a ɔde nneɛma ma a ɔwɔ mpɔtam hɔ nkyekyɛmu nhyehyɛe a ɛyɛ den a, ɛho hia yiye. FangService’s viscometer product line no kata ne nyinaa so firi entry-level so kɔsi professional, a ɛwɔ service outlets wɔ pharma nkuropɔn akɛseɛ mu wɔ Asia Kesee Fam Apueeɛ ne Afrika (Bangkok, Jakarta, Nairobi, Lagos).

Talent ho nsɛnnennen: Nnuruyɛ adwuma a ɛwɔ Asia Kesee Fam Apuei ne Afrika anya nkɔso ntɛmntɛm wɔ nnansa yi mfe mu, nanso QC mfiridwumayɛfo a wɔn ho akokwaw ho yɛ na koraa. Enti, sɛnea ɛyɛ mmerɛw sɛ wɔde bedi dwuma no yɛ ade titiriw a ɛma wɔpaw viscometer. NDJ-1E touchscreen rotational viscometer no intuitive interface ne preset method function ma adwumayɛfo a wɔwɔ ntetee kakraa bi no ma wotumi yɛ standard test procedures no yiye wɔ simma 10 mu.

Awiei-kɔ-Awiei a Wɔka Ho Ka: Efi R&D so kosi Production Line so

Viscosity sɔhwɛ wɔ pharma mu no trɛw nkɔnsɔnkɔnsɔn no nyinaa mu fi R&D kosi nea wɔyɛ so. Wɔ R&D mu no, ɛsɛ sɛ wɔn a wɔyɛ nnuru no hwehwɛ nnuru ahorow mu ntɛmntɛm sɛ ebia ɛwɔ viscosity su ahorow. Wɔ pilot-scale testing mu no, ɛsɛ sɛ wɔgye ɔkwan a wɔfa so yɛ no mpɛn pii ne pɛpɛɛpɛyɛ di dwuma. Wɔ adeyɛ mu no, ɛsɛ sɛ wɔhwɛ hu sɛ batch-to-batch hyia.

FangService no viscometer product line no kata afã abiɛsa no nyinaa so. Wɔ R&D ho no, wɔkamfo DV79A rotational viscometer — ɛboa ultra-wide range a ɛyɛ 0.1-1,000,000 mPa·s, a spindle ahorow 18 ne nneɛma pii, a ɛfata ma formulation nkɔso ahiade ahorow. Wɔ pilot ne production stages ho no, wɔkamfo DVPlus + series touchscreen viscometer kyerɛ — ɛboa data a wɔkora so, audit trails, ne user rights management, a ɛdi amanaman ntam mmara te sɛ 21 CFR Part 11 so.

Wɔ Asia Kesee Fam Apuei ne Afrika nnuruyɛ adwumayɛbea ahorow a wɔn sikasɛm tebea sua no, NDJ-1 ntoatoaso no de nsɛm a edi mũ ma fi R&D kosi QC. NDJ-1E + dijitaal rotational viscometer no boa 0.1-2,000,000 mPa·s, a Nos. 1-4 standard spindles ne ɔhyew nhwehwɛmu, a ɛdɔɔso ma dodow no ara anom nsu, injectable, ne topical ahosiesie viscosity sɔhwɛ. Ne modular nhyehyɛɛ kyerɛ sɛ nnwuma betumi afi ase de mfitiase nhyehyɛe na wɔde module ahorow a ɛyɛ adwuma aka ho bere a adwuma no nyin — titiriw wɔ gua a ɛrenya nkɔso a kapital sikasɛm nhyehyɛe yɛ den no mu.

Afotu a mfaso wɔ so: Pharma Viscosity Testing Lab a Wɔbɛhyehyɛ wɔ SEA ne Afrika

Sɛ wɔrehyehyɛ aduruyɛdan a wɔsɔ nnuru a ɛyɛ den hwɛ wɔ Asia Kesee Fam Apuei anaa Afrika a, ɛsɛ sɛ wosusuw nneɛma abiɛsa ho: nneɛma a atwa yɛn ho ahyia, ɛka a wɔbɔ, ne mmara.

Nneɛma a Atwa Yɛn Ho Ahyia: Fa lab mmeae a mframa titiriw wom anaasɛ mframa a wɔde yɛ adwuma nni hɔ di kan. Ɛsɛ sɛ viscometers nya ahoɔden a ɛtrɛw a ɛyɛ adwuma. FangService NDJ-1 ne DVPlus+ series no atwam wɔ nneɛma a atwa yɛn ho ahyia sɔhwɛ a ɛwɔ ɔhyew a ɛkorɔn, nsuo a ɛyɛ nwini kɛseɛ (40°C/90%RH, nnɔnhwerew 72), a ɛfata ma lab tebea a ɛtaa ba wɔ Asia Kesee Fam Apuei ne Afrika.

Ɛka: Fa ‘nnwinnade atitiriw + nneɛma atitiriw a wɔde boa’ adetɔ ho nhyehyɛe tom. NDJ-1E + dijitaal rotational viscometer biako (bɛyɛ RMB 15,000-20,000) a ɛwɔ aguaree a ɛyɛ hyew daa ne standard spindles betumi adi da biara da sɔhwɛ ahiade 80% ho dwuma. Sɛ adwumayɛ nkɔso hwehwɛ sɛ wɔyɛ pɛpɛɛpɛ a ɛkorɔn anaa nneɛma pii a, kɔ DVPlus + series no so. Mmara: Nnuruyɛ ho mmarahyɛ mpanyimfo a wɔwɔ Asia Kesee Fam Apuei aman mu (te sɛ Thailand FDA, Indonesia BPOM, Vietnam DAV) nyinaa hwehwɛ sɛ nnuruyɛ adwumayɛbea ahorow nya QC nhyehyɛe a ɛyɛ den. Ɛsɛ sɛ wotumi hwehwɛ viscosity testing data no mu na wotumi san yɛ bio. Viscometers a ɛne ISO 17025 hyia a wɔbɛpaw ne standard operating procedures (SOPs) a wɔde besi hɔ no yɛ ahwehwɛde atitiriw a ɛbɛma wɔatwam GMP akontabuo. FangService mfiridwuma kuw no betumi de mpɔtam hɔ kasa mu SOP nsusuwso ne adwumayɛ ho ntetee ama Asia Kesee Fam Apuei ne Afrika adetɔfo, na aboa nnwumakuw ma wɔatwa mmara ho akontaabu mu ntɛmntɛm. View the Viscosity Measurement Instruments Collection